Position: Sr. Manager, Value & Insights Team: Value, Engagement & Training (VET) Dep.: Product Owner Hub (POH) Location: Wuppertal, Germany

Our vision at Data Science Services & Solutions, DS3, is to Enable, Scale, and Operationalize R&D Data Science & AI capabilities to achieve Clinical Research and Development Speed, Efficiency, and Optimization. Learn more about our areas of responsibility, capabilities, strategic priorities, and collaborations. For more information, contact DS3 Head: Abi Velurethu. Artwork created using Stable Diffusion.

Given the considerable amount of data that is collected throughout clinical trials, it can be asked if this data can be used to improve our understanding of the trial, regardless of outcome. The radiomics pilot seeks to provide a toolkit that is capable of analyzing the different modalities of information found in clinical trials (genome, gene expression, biomarker, clinical information, and imaging information) to derive insights into why a patient may be responding, or why a clinical trial was unsuccessful. The current efforts have focused on clinical trials in oncology, while collaborating with the RED-ONC function. Overall, the project is in its pilot state, and demonstrating a proof of concept, while documenting many challenges and learnings with the development of such a toolkit. Potential directions that could expand this toolbox include deriving the factors that best predict why a patient would stay in a clinical trial, and providing assistance with patient selection of clinical trials. Other potential directions involve suggesting why a particular trial may have been unsuccessful and providing that information back to the drug development team.

The R&D Digital Fluency Program (DFP) is supporting you with learning offerings to build up competencies and further skillsets around digital technologies to enable a competitive and digitally literate organization. At the Digital Fluency Program, we set ourselves apart by offering learning opportunities created by your peers who understand the unique challenges you face in your job. Our tailored approach focuses on real-life use cases, taking our training far from generic and providing you relevant and impactful skill development. In 2020 we, a small team of four people, started our journey with the DFP as part of the R&D Digital Roadmap. Since technologies are ever evolving and impacting our work environment it is more important than ever to foster a culture of continuous learning and enable future opportunities. Thus the DFP learning portfolio includes something for everyone, regardless of your level of knowledge: It offers general awareness programs to enhance basic digital literacy, self-learning pathways on data analysis & visualization and the ability to access online courses like Coursera via the Digital Curriculum. The team ensured the learning objective was met by piloting newly developed learning programs, making use of cross-functional development, and incorporated R&D specific components prior to a broader roll-out in the organization.

Understanding how compounds affect the disease biology of patients, and which potential side effects could be expected, is one of the core challenges in drug discovery. Transcriptomics (RNA-seq) allows us to measure these compound effects via an unbiased readout of gene expression changes. While „conventional“ analysis of RNA-seq data yields insights into individual compound effects and similarities, deeper connections between principles of compound structure and transcriptome effect elude us. Insights into this connection would help us support project teams with data-driven decision making on compounds. In this pilot, we are bringing together a cross-functional team of colleagues from LST, CMD, SyMOL and DS&AI to tackle this challenge and build a toolkit to enable understanding of ​how compound structure relates to complex gene expression patterns​ and to explore common themes amongst structures or shared off-target/general perturbation effects. This toolbox will become the starting point for other efforts aimed at leveraging multi-omics data in understanding compound mechanism of actions. Artwork created using Stable Diffusion.

At Language of Life, LoL, we combine state-of-the-art machine learning models, bioinformatics and expert knowledge to understand and design large biomolecules (RNA, DNA, Proteins), helping deliver the best drug, faster and cheaper, to address our patients’ needs. Our objectives are, 1) Drug the undruggable 2) Target any modality 3) Efficient Dry lab – Wet lab loops 4) Understand Patient & Disease

I'm the Chief of staff for DS&AI. I'm the go-to-person for:​ Evolution of our strategy and culture​ Connecting the dots within and across the organization​ Topics you want to present to/discuss with the LT​

Hey there, I am Santi and I love applying machine learning to gain insight on hard problems. These days I mostly work with large biomolecules (RNA, DNA and proteins), but sometimes I also get lost in ginormous medical images. In the pic you can see me musing about the stunning architecture of the Reina Sofia Art Center. I hope Madrid was inspiring for you too! Drop me an email if you want to talk about it :-)